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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
37.88
Human Site:
Y246
Identified Species:
64.1
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
Y246
P
L
N
I
K
D
A
Y
E
D
P
R
F
N
A
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
Y246
P
L
N
I
K
D
A
Y
E
D
P
R
F
N
A
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
Y246
P
L
N
I
K
D
A
Y
E
D
P
R
F
N
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
Y236
P
L
N
I
K
D
A
Y
E
D
P
R
F
N
A
Rat
Rattus norvegicus
O54735
833
94538
R233
C
M
P
I
K
N
H
R
E
E
V
V
G
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
Y235
P
L
N
I
K
D
A
Y
E
D
P
R
F
N
A
Chicken
Gallus gallus
P52731
862
99990
N226
F
I
S
L
V
L
R
N
H
H
T
S
Y
L
Y
Frog
Xenopus laevis
NP_001088271
859
97399
Y227
P
L
N
I
K
D
A
Y
Q
D
S
R
F
N
A
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
Y231
P
L
N
I
K
N
A
Y
E
D
S
R
F
N
A
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
Y257
T
V
N
I
P
D
A
Y
Q
D
R
R
F
S
D
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
Y506
P
V
N
I
P
D
A
Y
Q
D
E
R
F
N
C
Honey Bee
Apis mellifera
XP_394107
1016
115998
Y284
I
I
N
I
K
D
A
Y
K
D
P
R
F
N
S
Nematode Worm
Caenorhab. elegans
P91119
710
81117
V161
E
K
S
I
V
N
A
V
C
T
W
A
A
A
T
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
C241
S
I
M
C
M
P
I
C
N
H
D
G
E
V
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
100
26.6
N.A.
100
0
86.6
86.6
53.3
66.6
73.3
13.3
0
P-Site Similarity:
100
100
100
N.A.
N.A.
100
46.6
N.A.
100
26.6
93.3
93.3
73.3
80
93.3
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
79
0
0
0
0
8
8
8
58
% A
% Cys:
8
0
0
8
0
0
0
8
8
0
0
0
0
0
8
% C
% Asp:
0
0
0
0
0
65
0
0
0
72
8
0
0
0
8
% D
% Glu:
8
0
0
0
0
0
0
0
50
8
8
0
8
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
72
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% G
% His:
0
0
0
0
0
0
8
0
8
15
0
0
0
0
0
% H
% Ile:
8
22
0
86
0
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
65
0
0
0
8
0
0
0
0
0
0
% K
% Leu:
0
50
0
8
0
8
0
0
0
0
0
0
0
8
0
% L
% Met:
0
8
8
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
72
0
0
22
0
8
8
0
0
0
0
65
0
% N
% Pro:
58
0
8
0
15
8
0
0
0
0
43
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
22
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
8
0
0
8
72
0
0
0
% R
% Ser:
8
0
15
0
0
0
0
0
0
0
15
8
0
8
8
% S
% Thr:
8
0
0
0
0
0
0
0
0
8
8
0
0
0
8
% T
% Val:
0
15
0
0
15
0
0
8
0
0
8
8
0
15
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
72
0
0
0
0
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _